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Table 4 Parameter values used in our model of the cardiovascular system with pulmonary arterial hypertension

From: A dynamical model for heart remodeling during the two phases of pulmonary arterial hypertension

  Left circuit Right circuit  
Development rate \(\overline {\alpha }_{\mathrm {l}}\) 9.75·10−5 \(\overline {\alpha }_{\mathrm {r}}\) = 2·10−5 mmHg.s/ml
Atrophy rate α l 3.9·10−6 α r = 8·10−7 mmHg.s/ml
Elastance coupling parameter Γ l= 9·10−4 Γ r = 9·10−4 ml-1
Backflow resistance limit \(R_{\mathrm {l}}^{*}\) 2.93 \(R_{\mathrm {r}}^{*}\) = 0.6 mmHg.s/ml
Circuit resistance * R s= 1.0 R p = 0.1 mmHg.s/ml
Ideal cardiac output * \(Q_{\text {il}}^{*}\) = 168.75 \(Q_{\text {ir}}^{*}\) = 150 ml/s
Increase rate of pulmonary resistance    Δ R p = 2.76·10−9 mmHg/ml
Damage rate σ l= 4·10−9 σ r = 4·10−9 Hz
Damage threshold \(\underline {\varepsilon }_{\mathrm {l}}\) = 10−3 \(\underline {\varepsilon }_{\mathrm {r}}\) = 10−3
  1. Parameters with a “*” were extracted from the literature
  2. This table contains parameter values specific to the left and right sides of the heart whereas general parameters (needed for the two parts of the heart) are reported in Table 3. To simulate a healthy subject, Δ R p=0 would be used