Table 9 The PK parameters for Equation11modeling doxorubicin for Gianni et al. [[27]] with paclitaxel present

1,2

$8.14\left|\frac{1-0.0254X_{\mathit{\text{DOX}},2}^{2.59}}{1+0.319X_{\mathit{\text{DOX}},2}^{1.59}}\right|\left|1+\frac{1.70X_{\mathit{\text{PTX}},1}}{1+0.000323X_{\mathit{\text{PTX}},1}}+\frac{0.233X_{\mathit{\text{PTX}},2}}{1+0.00193X_{\mathit{\text{PTX}},2}}\right|$

1,3

$3.08\left|\frac{1+3.12X_{\mathit{\text{DOX}},3}^{0.97}}{1+1.45X_{\mathit{\text{DOX}},3}^{0.97}}\right|$

1,4

$0.359\left|1+0.0001X_{\mathit{\text{DOX}},1}^{1.55}\right|\left|\frac{1+0.277X_{\mathit{\text{DOX}},4}^{1.63}}{1+0.0282X_{\mathit{\text{DOX}},4}^{0.25}}\right|$

2,0

$0.264\left|1-\frac{0.314X_{\mathit{\text{PTX}},2}}{1+0.0119X_{\mathit{\text{PTX}},2}}\right|$

2,1

$0.135\left|\frac{1+13.9X_{\mathit{\text{DOX}},1}^{0.87}}{1+0.167X_{\mathit{\text{DOX}},1}^{0.66}}\right|\left|1+\frac{3.08X_{\mathit{\text{PTX}},1}}{1+0.0441X_{\mathit{\text{PTX}},1}}-\frac{0.0003X_{\mathit{\text{PTX}},2}}{1+0.0078X_{\mathit{\text{PTX}},2}}\right|$

3,1

$0.0325\left|\frac{1+2.02X_{\mathit{\text{DOX}},1}^{1.74}}{1+0.143X_{\mathit{\text{DOX}},1}^{0.61}}\right|$

4,1

$0.0046\left|\frac{1+7.92X_{\mathit{\text{DOX}},1}^{1.04}}{1+0.243X_{\mathit{\text{DOX}},1}^{1.95}}\right|$