Skip to main content

Advertisement

Table 2 Comparison between in vitro and in vivo parameter values

From: Modeling domain formation of MARCKS and protein kinase C at cellular membranes

Molecule Parameter Meaning Value in vitro Fit on Figure2
PKC     
  k b pkc Binding 40 s -1[53] 400 s -1
  k u pkc Unbinding 10 s -1[53] 1 s -1
MARCKS     
  k b mrk Binding 10-400 s -1[12] 4 ×103 s -1
  k u mrk Unbinding 10 s -1[12] 0.1 s -1
  k pkc mrk Phosphorylation 0.25 μ M -1 s -1