Figure 8

Phase diagram of the model for different values of the diffusion at the membrane D _m and in the cytosol D _c . Solid lines corresponds to simulations of a cell with radius R=10 μ m. Dashed lines correspond to simulations of cells with radius R=7.5 μ m and R=12.5 μ m. Above the line the homogeneous protein distribution is stable. Below the line, protein domain formation at the membrane under small random initial perturbations (a) and bistability-induced protein domain formation under large perturbations (b) are observed. Crosses mark the parameter values employed in Figures 5 and 6.