A model of the network organization of partial seizures. The brain structures are represented by letters (A,B, etc.). The scheme proposes the existence of two groups of structures in the epileptic brain. Some of them are able to generate seizures, and particularly fast discharges at seizure onset. They constitue the EZ network (labelled A,B,C,D). A represents a region with putative (visible) lesion. The EZ network produces rapid discharge and is characterized by a pattern of Synchrony-Desynchrony. A second set of structures are less epileptogenic and are triggered in seizures by the EZ (“propagation zone network”, structures (E,F,SC, H). SC correspond to subcortical (thalamus for instance) regions. Activity recorded in these regions are of lower frequency and generally more synchronized than in the EZ. The Propagation zone network can in turn synchronize with the EZ network during the course of the seizure.