Functional connectivity during ictal emotional manifestations. a. Intracerebral EEG recordings (SEEG) in a patient with acute emotional disturbances during a temporal lobe seizure. Clinical onset corresponded to the appearance of screaming, fear and anger facial expression with defensive aggression against the examiner (Kiking, boxing movements). Traces show the signals recorded from the amygdala (A) and the orbito-frontal cortex (OFC). Clinical onset is associated with a desynchrony (decrease in correlation values between the two signals) between the two signals. b. Graphs showing the interactions between brain regions during seizures. Mean correlation values computed over the IP period, between 2 given structures, are indicated on corresponding lines. Solid lines indicate an increase in synchronization during the IP period (> 2 SD in comparison with BKG period) and dotted lines indicate a decrease in synchronization during the IP period (< 2SD in comparison with BKG period). Finally the most constant pattern is a desynchronisation between the orbitofrontal cortex (OFC) and the amygdala (A). Other studied regions include the dorsolateral prefrontal cortex (DLPFC), the cingulate regions BA32 and BA24 (CG32 and CG24) and the temporal pole (TP). c. Scheme illustrating the desynchronization between amygdala and orbitofrontal cortex, a pattern found in the three studied cases at seizure onset. Adapted from .