Fig. 7
From: Reduction of calcium release site models via optimized state aggregation
Transition diagram of the four-state Ca2+ channel model. The channel is activated by cytosolic Ca2+ (transitions C u →O u and C s →O s ) and is “sensitized” by ER/SR Ca2+ (transitions C u →C s and O u →O s ). Parameters: \(k_{a}^{+} = k_{d}^{+} = 4.5\ \mu {M}^{-2}{ms}^{-1}\), \(k_{c}^{+} = k_{e}^{+} = 1\ \mu {M}^{-1}{ms}^{-1}, k_{a}^{-} = k_{d}^{-} = 500\ {ms}^{-1}, \ c_{{cyt}} = 0.1\ \mu \)M