Fig. 1
From: A dynamical model for heart remodeling during the two phases of pulmonary arterial hypertension
Schematic progression of a pulmonary vascular disease and its effects on the heart and pulmonary arteries geometry. Starting from a physiological situation (a), the pulmonary arterial pressure slightly increases, inducing an hypertrophy of the right ventricle and a slight vasoconstriction of pulmonary arteries associated with an early loss of endothelial cells: this is the compensation phase (b). A significant increase of the pulmonary arterial pressure due to a strong diameter reduction of pulmonary arteries induces a serious inflation of the right ventricle associated with an endothelial cells proliferation: this is the failure (decompensation) phase (c). Adapted from [5]