Optimization of combination chemotherapy based on the calculation of network entropy for protein-protein interactions in breast cancer cell lines

EPJ Nonlinear Biomedical Physics

Table 3 The panel of targeted drugs classified according to their therapeutic targets, primary effector pathways, or signaling pathway; and the sensitivity for each malignant cell lines

Drugs group	HSP90*	PI3K-AKT¥	mTOR†	Angiog. ^‡	EGFR Retal^₤	MT/Cyts^**	RasRaf^***	Cell cycle ^∘	HDAC^∘∘	Average
Targets	I^∘∘∘	II††	III^‡‡	IV^₤₤	V^a	VI^b	VII^c	VIII^d	IX^e
L^f
MCF-7	6.43	5.92	6.32	4.47	4.65	7.27	4.99	5.57	5.54	5.69
T-47D	NA	6.21	6.08	4.56	4.62	6.33	4.63	5.49	5.57	5.44
ZR-75-1	6.74	5.66	4.18	4.41	4.57	6.91	4.95	5.13	5.22	5.31
BT-474	7.77	6.42	7.84	4.58	5.73	6.93	4.55	5.14	5.82	6.09
Correl.^g	−0.462	−0.746	−0.953	−0.699	−0.704	−0.327	0.420	−0.222	−0.918	−0.923
TN^h
BT-20	NA	5.38	6.99	4.47	4.99	7.00	4.81	5.40	5.09	5.52
MDA-MB-231	6.82	5.06	5.45	4.42	4.65	7.70	5.22	5.18	4.68	5.47
MDA-MB-468	6.59	5.70	5.40	4.38	4.90	7.78	4.78	6.31	5.19	5.67
Correl.	1.000	−0.504	0.877	0.998	0.245	−0.905	0.064	−0.764	−0.189	−0.725
Tot. correl.ⁱ	−0.391	−0.605	−0.528	−0.411	−0.546	−0.205	0.351	−0.298	−0.588	−0.859

*HSP90: Heat shock protein 90; ¥PI3K-AKT: Phosphatidylinositol 3′ -kinase(PI3K)-Akt signaling pathway; ^†mTOR: Mammalian target of rapamycin; ^‡Angiog.: Angiogenesis ; ₤EGFR Retal: EGFR/FGFR/HER2/IGFR pathway; ^**MT/Cyt: microtubule/cytoskeleton; ^***RasRaf: Ras-Raf-MEK-MAPK-ERK pathway; ∘Cell cycle: cell cycle involved proteins ; ∘∘HDAC: histone deacetylases; ∘∘∘I: HSP90AA1; ^††II: AKT, AKT1, AKT2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, ZNF217; ^‡‡III: mTOR; ₤₤IV: MMP2, MMP9, VEGFR2
^aV: EGFR, ERBB2, ESR1, FGFR3, IGF1R
^bVI: BCL2, CENPE, Kinesin, ROCK2, TUBB, TUBB1, TUBB3
^cVII: BRAF, ELK3, MAP2K1, MAP2K2, MAPK9, MAPK10
^dVIII: AURKA, AURKB, AURKC, CCNB1, CDC25A, CDC25B, CDC25C, CDK1, CDK4, CHEK1, NAE1, PLK1, polyamine analogue
^eIX:HDAC
^fL: Luminal
^gCorrelation of drug GI50 with entropy per node (see Table 1)
^hTN: Triple-negative
ⁱTot. correl: correlation for L and TN together