Skip to main content

Table 3 The panel of targeted drugs classified according to their therapeutic targets, primary effector pathways, or signaling pathway; and the sensitivity for each malignant cell lines

From: Optimization of combination chemotherapy based on the calculation of network entropy for protein-protein interactions in breast cancer cell lines

Drugs group HSP90* PI3K-AKT¥ mTOR† Angiog. EGFR Retal MT/Cyts** RasRaf*** Cell cycle HDAC Average
Targets I II†† III‡‡ IV₤₤ Va VIb VIIc VIIId IXe  
Lf           
MCF-7 6.43 5.92 6.32 4.47 4.65 7.27 4.99 5.57 5.54 5.69
T-47D NA 6.21 6.08 4.56 4.62 6.33 4.63 5.49 5.57 5.44
ZR-75-1 6.74 5.66 4.18 4.41 4.57 6.91 4.95 5.13 5.22 5.31
BT-474 7.77 6.42 7.84 4.58 5.73 6.93 4.55 5.14 5.82 6.09
Correl.g −0.462 −0.746 −0.953 −0.699 −0.704 −0.327 0.420 −0.222 −0.918 −0.923
TNh           
BT-20 NA 5.38 6.99 4.47 4.99 7.00 4.81 5.40 5.09 5.52
MDA-MB-231 6.82 5.06 5.45 4.42 4.65 7.70 5.22 5.18 4.68 5.47
MDA-MB-468 6.59 5.70 5.40 4.38 4.90 7.78 4.78 6.31 5.19 5.67
Correl. 1.000 −0.504 0.877 0.998 0.245 −0.905 0.064 −0.764 −0.189 −0.725
Tot. correl.i −0.391 −0.605 −0.528 −0.411 −0.546 −0.205 0.351 −0.298 −0.588 −0.859
  1. *HSP90: Heat shock protein 90; ¥PI3K-AKT: Phosphatidylinositol 3′ -kinase(PI3K)-Akt signaling pathway; mTOR: Mammalian target of rapamycin; Angiog.: Angiogenesis ; ₤EGFR Retal: EGFR/FGFR/HER2/IGFR pathway; **MT/Cyt: microtubule/cytoskeleton; ***RasRaf: Ras-Raf-MEK-MAPK-ERK pathway; Cell cycle: cell cycle involved proteins ; HDAC: histone deacetylases; I: HSP90AA1; ††II: AKT, AKT1, AKT2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, ZNF217; ‡‡III: mTOR; ₤₤IV: MMP2, MMP9, VEGFR2
  2. aV: EGFR, ERBB2, ESR1, FGFR3, IGF1R
  3. bVI: BCL2, CENPE, Kinesin, ROCK2, TUBB, TUBB1, TUBB3
  4. cVII: BRAF, ELK3, MAP2K1, MAP2K2, MAPK9, MAPK10
  5. dVIII: AURKA, AURKB, AURKC, CCNB1, CDC25A, CDC25B, CDC25C, CDK1, CDK4, CHEK1, NAE1, PLK1, polyamine analogue
  6. eIX:HDAC
  7. fL: Luminal
  8. gCorrelation of drug GI50 with entropy per node (see Table 1)
  9. hTN: Triple-negative
  10. iTot. correl: correlation for L and TN together