Self-organisation of curved microtubules, at crowded conditions in vitro, is guided by breaking the symmetry of initially homogenous space, that reflects the presence of massive spatio-time correlations, i.e. immanent principle of synergy. Electron-microscopy (EM), filtered image of microtubules fibers at 12500×. A. Several curved and entangled fibers constituted by curved microtubules, at 7 mg/ml MTP and 1 mM Ca2+ in excess. B. Curved fibers spontaneously self-organize into a spatial patterns of higher complexity (network) in vitro, at higher microtubule protein (MTP) concentration (10 mg/ml), and 1 mM Ca2+ in excess. Curved fibers are constituted of partially parallel curved microtubules, they are multiple crossing each other at other locations, while microtubule free locations are formed as well.