Self-organisation of straight microtubules, at crowded conditions in vitro is guided by breaking the symmetry of initially homogenous space, that reflects the presence of massive spatio-time correlations, i.e. immanent principle of synergy. A. Fibers constituted by straight microtubules. Electron-microscopy (EM), filtered, image at 12500×, in vitro at 7 mg/ml of microtubule protein concentration, and 360°C. B. Straight fibers spontaneously self-organize into a spatial patterns of higher complexity (network) in vitro, at higher microtubule protein (MTP) concentration (10 mg/ml). Predominantly straight microtubules retain partial parallel ordering pattern in some locations, they are multiple crossing each other at other locations, while microtubule free locations are formed as well.