Table 8 The PK parameters for Equation 11 modeling 6 α -hydroxypaclitaxel

1,2

1

1

21.3666

$12.2\left|\frac{1-0.523X_{\mathit{\text{OHP}},2}}{1+0.204X_{\mathit{\text{OHP}},2}}\right|$

1,3

1

1

0.0808

1.67|1+0.166X_{O H P,3}|

2,0

1

1

0.0000

23.9

2,1

1

1

0.0000

0.103|1+0.0182X_{O H P,2}||1+2.54X_{O H P,1}|

3,1

1

1

0.0000

$0.0468\left|1+0.0975X_{\mathit{\text{OHP}},3}\right|\left|\frac{1-15.2X_{\mathit{\text{OHP}},1}}{1+28.9X_{\mathit{\text{OHP}},1}}\right|$