A multi-compartment pharmacokinetic model of the interaction between paclitaxel and doxorubicin

EPJ Nonlinear Biomedical Physics

Table 7 The PK parameters for Equation 11 modeling paclitaxel

j,k	A _{P T X,j,k}	B _{P T X,j,k}	Γ _{P T X,j,k}	K _{P T X,j,k}
1,2	1.06	1.79	0.0001	$13.8 1 + 0.0117 X PTX, 2 1.05 1 + 3.37 X PTX, 2 0.96$
1,3	1.40	1.62	0.0000	$29.1 1 − 0.0002 X PTX, 1 1.68 1 + 0.0004 X PTX, 3 1.24 1 + 0.551 X PTX, 3 1.22$
1,4	1.23	1.10	0.0000	$2.85 1 + 0.0082 X PTX, 4 1.01 1 + 0.117 X PTX, 4 1.22$
2,0	1.03	1.99	0.0876	$2.98 1 − 0.0023 X PTX, 2 2.09$
2,1	0.94	1.09	0.0028	$0.0523 1 − 0.0023 X PTX, 1 0.97 1 + 0.0015 X PTX, 1 1.32$
3,1	1.66	1.93	0.00003	$0.0230 1 + 0.0423 X PTX, 1 1.75 1 + 0.0199 X PTX, 1 1.60$
4,1	1.78	1.83	0.0009	$0.0061 1 − 0.0054 X PTX, 1 0.89 1 + 6.36 X PTX, 1 0.74$