Table 6 The PK parameters for Equation11modeling doxorubicinol for Moreira et al. [[28]]

1,2

1.57

2.51

0.3261

$15.9\left|\frac{1+14.0X_{\mathit{\text{DOL}},2}^{0.50}}{1+8.04X_{\mathit{\text{DOL}},2}^{1.24}}\right|$

1,3

1.20

1.00

0.0000

$4.82\left|1+0.0749X_{\mathit{\text{DOL}},1}^{0.95}\right|\left|\frac{1+0.711X_{\mathit{\text{DOL}},3}^{1.22}}{1+0.0433X_{\mathit{\text{DOL}},3}^{1.26}}\right|$

2,0

0.66

2.36

1.3731

$13.8\left|1-0.0162X_{\mathit{\text{DOL}},2}^{2.07}\right|$

2,1

0.61

2.02

4.5141

$5.03\left|1+0.0690X_{\mathit{\text{DOL}},2}^{1.11}\right|\left|\frac{1+0.135X_{\mathit{\text{DOL}},1}^{0.91}}{1+2.61X_{\mathit{\text{DOL}},1}^{1.37}}\right|$

3,1

0.60

1.00

0.0000

$0.0479\left|1+0.0047X_{\mathit{\text{DOL}},3}^{1.10}\right|\left|\frac{1-7.87X_{\mathit{\text{DOL}},1}^{1.45}}{1+2.33X_{\mathit{\text{DOL}},1}^{1.22}}\right|$