Table 5 The PK parameters for Equation11modeling doxorubicin for Moreira et al. [[28]]

1,2

0.86

2.14

0.0005

$8.86\left|\frac{1-0.0231X_{\mathit{\text{DOX}},2}^{3.12}}{1+0.157X_{\mathit{\text{DOX}},2}^{0.89}}\right|$

1,3

1.06

1.87

0.0036

$3.69\left|\frac{1+3.09X_{\mathit{\text{DOX}},3}}{1+1.61X_{\mathit{\text{DOX}},3}}\right|$

1,4

2.07

0.86

0.0007

$0.375\left|1+0.0003X_{\mathit{\text{DOX}},1}^{2.99}\right|\left|\frac{1+0.375X_{\mathit{\text{DOX}},4}^{1.59}}{1+0.0222X_{\mathit{\text{DOX}},4}^{0.31}}\right|$

2,0

1.38

1.00

0.0000

0.264

2,1

0.91

0.51

0.2295

$0.102\left|\frac{1+11.2X_{\mathit{\text{DOX}},1}^{0.90}}{1+0.181X_{\mathit{\text{DOX}},1}^{0.91}}\right|$

3,1

1.02

0.90

0.0264

$0.0369\left|\frac{1+1.74X_{\mathit{\text{DOX}},1}^{0.96}}{1+0.298X_{\mathit{\text{DOX}},1}^{1.48}}\right|$

4,1

1.82

1.00

0.0000

$0.0052\left|\frac{1+6.42X_{\mathit{\text{DOX}},1}^{1.02}}{1+0.154X_{\mathit{\text{DOX}},1}^{2.17}}\right|$