A multi-compartment pharmacokinetic model of the interaction between paclitaxel and doxorubicin

EPJ Nonlinear Biomedical Physics

Table 5 The PK parameters for Equation11modeling doxorubicin for Moreira et al. [[28]]

j,k	A _{D O X,j,k}	B _{D O X,j,k}	Γ _{D O X,j,k}	K _{D O X,j,k}
1,2	0.86	2.14	0.0005	$8.86 1 − 0.0231 X DOX, 2 3.12 1 + 0.157 X DOX, 2 0.89$
1,3	1.06	1.87	0.0036	$3.69 1 + 3.09 X DOX, 3 1 + 1.61 X DOX, 3$
1,4	2.07	0.86	0.0007	$0.375 1 + 0.0003 X DOX, 1 2.99 1 + 0.375 X DOX, 4 1.59 1 + 0.0222 X DOX, 4 0.31$
2,0	1.38	1.00	0.0000	0.264
2,1	0.91	0.51	0.2295	$0.102 1 + 11.2 X DOX, 1 0.90 1 + 0.181 X DOX, 1 0.91$
3,1	1.02	0.90	0.0264	$0.0369 1 + 1.74 X DOX, 1 0.96 1 + 0.298 X DOX, 1 1.48$
4,1	1.82	1.00	0.0000	$0.0052 1 + 6.42 X DOX, 1 1.02 1 + 0.154 X DOX, 1 2.17$