Table 4 The PK parameters for Equation11modeling doxorubicinol for Gianni et al. [[27]]

1,2

1.76

2.43

0.3371

$14.0\left|\frac{1+10.6X_{\mathit{\text{DOL}},2}^{0.72}}{1+4.54X_{\mathit{\text{DOL}},2}^{1.92}}\right|$

1,3

1.07

1.00

0.0000

$3.92\left|1+0.1150X_{\mathit{\text{DOL}},1}^{0.55}\right|\left|\frac{1+1.02X_{\mathit{\text{DOL}},3}^{1.52}}{1+0.0482X_{\mathit{\text{DOL}},3}^{2.43}}\right|$

2,0

0.72

1.83

1.5722

$8.58\left|1-0.0167X_{\mathit{\text{DOL}},2}^{1.55}\right|$

2,1

0.91

1.34

6.8599

$3.90\left|1+0.0646X_{\mathit{\text{DOL}},2}^{1.18}\right|\left|\frac{1+0.1282X_{\mathit{\text{DOL}},1}^{0.95}}{1+3.97X_{\mathit{\text{DOL}},1}^{1.07}}\right|$

3,1

0.79

1.00

0.0000

$0.0594\left|1+0.0073X_{\mathit{\text{DOL}},3}^{2.26}\right|\left|\frac{1-6.94X_{\mathit{\text{DOL}},1}^{1.17}}{1+3.19X_{\mathit{\text{DOL}},1}^{0.96}}\right|$