A multi-compartment pharmacokinetic model of the interaction between paclitaxel and doxorubicin

EPJ Nonlinear Biomedical Physics

Table 3 The PK parameters for Equation11modeling doxorubicin for Gianni et al. [[27]]

j,k	A _{D O X,j,k}	B _{D O X,j,k}	Γ _{D O X,j,k}	K _{D O X,j,k}
1,2	0.79	2.52	0.0006	$8.14 1 − 0.0254 X DOX, 2 2.59 1 + 0.319 X DOX, 2 1.59$
1,3	0.83	2.43	0.0039	$3.08 1 + 3.12 X DOX, 3 0.97 1 + 1.44 X DOX, 3 0.97$
1,4	1.59	1.62	0.0012	$0.359 1 + 0.0001 X DOX, 1 1.55 1 + 0.277 X DOX, 4 1.63 1 + 0.0282 X DOX, 4 0.25$
2,0	1.33	1.00	0.0000	0.264
2,1	1.01	0.53	0.0994	$0.135 1 + 13.9 X DOX, 1 0.87 1 + 0.1672 X DOX, 1 0.66$
3,1	1.04	1.12	0.0287	$0.0325 1 + 2.02 X DOX, 1 1.74 1 + 0.143 X DOX, 1 0.61$
4,1	1.79	1.00	0.0000	$0.0046 1 + 7.92 X DOX, 1 1.04 1 + 0.243 X DOX, 1 1.95$