Table 3 The PK parameters for Equation11modeling doxorubicin for Gianni et al. [[27]]

1,2

0.79

2.52

0.0006

$8.14\left|\frac{1-0.0254X_{\mathit{\text{DOX}},2}^{2.59}}{1+0.319X_{\mathit{\text{DOX}},2}^{1.59}}\right|$

1,3

0.83

2.43

0.0039

$3.08\left|\frac{1+3.12X_{\mathit{\text{DOX}},3}^{0.97}}{1+1.44X_{\mathit{\text{DOX}},3}^{0.97}}\right|$

1,4

1.59

1.62

0.0012

$0.359\left|1+0.0001X_{\mathit{\text{DOX}},1}^{1.55}\right|\left|\frac{1+0.277X_{\mathit{\text{DOX}},4}^{1.63}}{1+0.0282X_{\mathit{\text{DOX}},4}^{0.25}}\right|$

2,0

1.33

1.00

0.0000

0.264

2,1

1.01

0.53

0.0994

$0.135\left|\frac{1+13.9X_{\mathit{\text{DOX}},1}^{0.87}}{1+0.1672X_{\mathit{\text{DOX}},1}^{0.66}}\right|$

3,1

1.04

1.12

0.0287

$0.0325\left|\frac{1+2.02X_{\mathit{\text{DOX}},1}^{1.74}}{1+0.143X_{\mathit{\text{DOX}},1}^{0.61}}\right|$

4,1

1.79

1.00

0.0000

$0.0046\left|\frac{1+7.92X_{\mathit{\text{DOX}},1}^{1.04}}{1+0.243X_{\mathit{\text{DOX}},1}^{1.95}}\right|$