Table 2 The PK parameters for Equation 11 modeling doxorubicinol

1,2

2.11

1.41

0.5836

$12.1\left|\frac{1+10.5X_{\mathit{\text{DOL}},2}^{0.89}}{1+4.65X_{\mathit{\text{DOL}},2}^{1.67}}\right|$

1,3

1.19

1.00

0.0000

$3.41\left|1+0.0702X_{\mathit{\text{DOL}},1}^{0.90}\right|\left|\frac{1+0.967X_{\mathit{\text{DOL}},3}^{1.92}}{1+0.0466X_{\mathit{\text{DOL}},3}^{1.42}}\right|$

2,0

0.79

1.36

1.8532

$8.86\left|1-0.0228X_{\mathit{\text{DOL}},2}^{1.20}\right|$

2,1

1.03

1.08

8.5081

$3.30\left|1+0.0368X_{\mathit{\text{DOL}},2}^{2.09}\right|\left|\frac{1+0.0943X_{\mathit{\text{DOL}},1}^{1.43}}{1+3.86X_{\mathit{\text{DOL}},1}^{0.76}}\right|$

3,1

0.64

1.00

0.0000

$0.0601\left|1+0.0054X_{\mathit{\text{DOL}},3}^{1.29}\right|\left|\frac{1-5.87X_{\mathit{\text{DOL}},1}^{1.68}}{1+2.38X_{\mathit{\text{DOL}},1}^{1.20}}\right|$