Table 12 The PK parameters for Equation11modeling doxorubicinol for Moreira et al. [[28]] with paclitaxel present

1,2

$15.9\left|\frac{1+14.0X_{\mathit{\text{DOL}},2}^{0.50}}{1+8.04X_{\mathit{\text{DOL}},2}^{1.24}}\right|\left|1+\frac{7.23X_{\mathit{\text{PTX}},1}^{0.66}}{1+0.0070X_{\mathit{\text{PTX}},1}^{1.46}}-\frac{0.701X_{\mathit{\text{PTX}},2}^{0.28}}{1+0.0005X_{\mathit{\text{PTX}},2}^{6.85}}\right|$

1,3

$4.82\left|1+0.0749X_{\mathit{\text{DOL}},1}^{0.95}\right|\left|\frac{1+0.711X_{\mathit{\text{DOL}},3}^{1.22}}{1+0.0433X_{\mathit{\text{DOL}},3}^{1.26}}\right|$

2,0

$13.8\left|1-0.0162X_{\mathit{\text{DOL}},2}^{2.07}\right|\left|1-\frac{0.131X_{\mathit{\text{PTX}},2}^{1.37}}{1+0.0004X_{\mathit{\text{PTX}},2}^{6.68}}\right|$

2,1

$5.03\left|1+0.0690X_{\mathit{\text{DOL}},2}^{1.11}\right|\left|\frac{1+0.135X_{\mathit{\text{DOL}},1}^{0.91}}{1+2.61X_{\mathit{\text{DOL}},1}^{1.37}}\right|\left|1-\frac{0.0434X_{\mathit{\text{PTX}},1}^{1.10}}{1+0.0103X_{\mathit{\text{PTX}},1}^{2.41}}+\frac{10.9X_{\mathit{\text{PTX}},2}^{1.12}}{1+0.00007X_{\mathit{\text{PTX}},2}^{6.94}}\right|$

3,1

$0.0479\left|1+0.0047X_{\mathit{\text{DOL}},3}^{1.10}\right|\left|\frac{1-7.87X_{\mathit{\text{DOL}},1}^{1.45}}{1+2.33X_{\mathit{\text{DOL}},1}^{1.22}}\right|$