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Table 11 The PK parameters for Equation11modeling doxorubicin for Moreira et al. [[28]] with paclitaxel present

From: A multi-compartment pharmacokinetic model of the interaction between paclitaxel and doxorubicin

j,k K D O X,j,k
1,2 8.86 1 0.0231 X DOX , 2 3.12 1 + 0.157 X DOX , 2 0.89 1 + 0.0010 X PTX , 1 1 + 0.00002 X PTX , 1 0.0003 X PTX , 2 1 + 0.106 X PTX , 2
1,3 3.69 1 + 3.09 X DOX , 3 1.02 1 + 1.61 X DOX , 3 0.95
1,4 0.375 1 + 0.0003 X DOX , 1 2.99 1 + 0.375 X DOX , 4 1.59 1 + 0.0222 X DOX , 4 0.31
2,0 0.264 1 + 0.00002 X DOX , 2 1.90 1 0.498 X PTX , 2 1 + 0.101 X PTX , 2
2,1 0.102 1 + 0.00001 X DOX , 2 1.71 1 + 11.2 X DOX , 1 0.90 1 + 0.181 X DOX , 1 0.91 1 0.0010 X PTX , 1 1 + 0.00002 X PTX , 1 + 0.240 X PTX , 2 1 + 0.350 X PTX , 2
3,1 0.0369 1 + 1.74 X DOX , 1 0.96 1 + 0.298 X DOX , 1 1.48
4,1 0.0052 1 0.00001 X DOX , 4 1.14 1 + 6.42 X DOX , 1 1.02 1 + 0.154 X DOX , 1 2.17