Skip to main content

Table 10 The PK parameters for Equation11modeling doxorubicinol for Gianni et al. [[27]] with paclitaxel present

From: A multi-compartment pharmacokinetic model of the interaction between paclitaxel and doxorubicin

j,k K D O L,j,k
1,2 14.0 1 + 10.6 X DOL , 2 0.72 1 + 4.54 X DOL , 2 1.67 1 0.00008 X PTX , 1 0.39 1 + 0.00007 X PTX , 1 3.64 0.0368 X PTX , 2 3.10 1 + 0.00001 X PTX , 2 0.60
1,3 3.92 1 + 0.115 X DOL , 1 0.55 1 + 1.02 X DOL , 3 1.52 1 + 0.0482 X DOL , 3 2.43 1 0.00095 X PTX , 1 3.26 1 + 0.00006 X PTX , 1 5.09 0.0003 X PTX , 3 2.64 1 + 0.0001 X PTX , 3 2.58
2,0 8.58 1 0.0167 X DOL , 2 1.55 1 0.0426 X PTX , 2 0.457 1 + 0.00004 X PTX , 2 2.28
2,1 3.90 1 + 0.0646 X DOL , 2 1.18 1 + 0.128 X DOL , 1 0.95 1 + 3.97 X DOL , 1 1.07 1 + 0.0223 X PTX , 1 2.22 1 + 0.00004 X PTX , 1 0.21 + 1.11 X PTX , 2 0.52 1 + 0.00001 X PTX , 2 1.12
3,1 0.0594 1 + 0.0073 X DOL , 3 2.26 1 6.94 X DOL , 1 1.17 1 + 3.19 X DOL , 1 0.96 1 0.00003 X PTX , 1 2.50 1 + 0.00002 X PTX , 1 0.60 + 0.0010 X PTX , 3 3.31 1 + 0.00004 X PTX , 3 5.16