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Table 1 The PK parameters for Equation 11 modeling doxorubicin

From: A multi-compartment pharmacokinetic model of the interaction between paclitaxel and doxorubicin

j,k A D O X,j,k B D O X,j,k Γ D O X,j,k K D O X,j,k
1,2 0.90 1.99 0.0005 8.77 1 0.017 X DOX , 2 1.78 1 + 0.189 X DOX , 2 1.03
1,3 1.08 1.71 0.0038 3.55 1 + 3.09 X DOX , 3 1 + 1.53 X DOX , 3
1,4 1.97 0.96 0.0008 0.354 1 + 0.0002 X DOX , 1 2.77 1 + 0.306 X DOX , 4 1.51 1 + 0.0253 X DOX , 4 0.40
2,0 0.94 1.00 0.0000 0.252
2,1 0.72 0.80 0.1466 0.132 1 + 9.35 X DOX , 1 0.96 1 + 0.020 X DOX , 1 0.84
3,1 0.97 1.16 0.0242 0.0325 1 + 2.40 X DOX , 1 1.34 1 + 0.165 X DOX , 1 1.01
4,1 1.91 1.00 0.0000 0.0055 1 + 6.67 X DOX , 1 0.86 1 + 0.15 X DOX , 1 1.27