Patient airflow (A) and simulated curve (B). Case of a 45 years old male. (BMI =35.4 kg.m −1) with an OHS and a sleep apnea syndrome, ventilated with a VPAP III ventilator (ResMed) in a pressure support mode. Pressure values: P
=22 cmH 2O and P
=5 cmH 2O. These values were also used with the mechanical lung. We set P0.1=1 cmH 2O, R=5 cmH 2O/l/s, and C=20 ml/cmH 2O, as commonly used for a restrictive patient (the actual values were not measured).